Laboratory Medicine

Biological Mass Spectrometry by A. L. Burlingame (Eds.)

By A. L. Burlingame (Eds.)

This quantity describes and integrates the strategies and basics of greater than a decade of innovative advances in either chromatographic and mass spectrometric applied sciences that experience enabled the direct research of biomacromolecules consistent with se and feature supplied the analytical energy base to bring in the recent fields of proteomics and platforms biology.

It additionally covers new biophysical purposes resembling H/D trade for learn of conformations, protein-protein and protein-metal and ligand interactions. ultimately it describes atto-to-zepto-mole quantitation of 14C and 3H via accelerator mass spectrometry.

*Part 1 of two volumes approximately Mass Spectrometry
*Authoritative and complete remedy of protein mass spectrometry in human mobile biology
*Presents basics, recommendations, instrumentation and bioinformatics
*Provides an summary of proteomics, protein-protein and protein-ligand binding, and biophysical reviews

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1995). Mass resolution improvement by incorporation of pulsed ion extraction in a matrix‐assisted laser desorption/ionization linear time‐of‐flight mass spectrometer. Anal. Chem. 67, 1998. Burlingame, A. , Carr, S. , and Baldwin, M. A. ) (2000). ’’ Humana, Totowa, NJ. Carr, S. , Huddleston, M. , and Annan, R. S. (1996). Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry. Anal. Biochem. 239, 180–192. , and Wollnik, H. (2001). Multipass time‐of‐flight mass spectrometers with high resolving powers.

Humana, Totowa, NJ. Carr, S. , Huddleston, M. , and Annan, R. S. (1996). Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry. Anal. Biochem. 239, 180–192. , and Wollnik, H. (2001). Multipass time‐of‐flight mass spectrometers with high resolving powers. Int. J. Mass Spectrom. 206, 267–273. Cech, N. , and Enke, C. G. (2000). Relating electrospray ionization response to nonpolar character of small peptides. Anal. Chem. 72, 2717–2723. Chernushevich, I.

Chem. 66, 4390–4399. McCloskey, J. A. ) (1990). In Mass Spectrometry, 193. McLafferty, F. , and Turecek, F. (1993). ‘‘Interpretation of Mass Spectra,’’ 4 Ed. University Science Books, Mill Valley, CA. [1] mass spectrometers for biomolecular analysis 47 Medzihradszky, K. , Adams, G. , Burlingame, A. , Bateman, R. , and Green, M. R. (1996). Peptide sequence determination by matrix‐assisted laser desorption ionization employing a tandem double focusing magnetic‐orthogonal acceleration time‐of‐flight mass spectrometer.

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