Environmental Studies

Biochemistry of Halogenated Organic Compounds by Kenneth L. Kirk

By Kenneth L. Kirk

Biochemistry of Halogenated natural Compounds has been written as a normal reference resource for researchers in different similar components, together with natural chemists, medicinal chemists, pharmacologists, toxicologists, and clinical researchers. the advance of halogenated compounds as medicinal brokers and pharmacological instruments and the interesting biochemi­ cal procedures which were chanced on and studied utilizing those analogues have generated tremendous energetic components of analysis and an immense quantity of literature. therefore, halogenated natural compounds pervade each element of biochemistry, a truth made obvious through the varied reports and monographs on hand on person topics-halogenated nucleosides, halogenated carbohydrates, and so on. Given the amount of fabric already written on those issues, a few of which fabric is sort of present, it'd be requested no matter if a one-volume evaluate of those matters comes in handy, or attainable. Having now accomplished this paintings, i believe the reply to either questions is an emphatic certain. There are interesting tales to be similar in every one region, and, the place applicable, i've got tried to enhance those issues . from a ancient standpoint. for instance, the invention of the anticancer job of fluorouracil, the unraveling of the different mechanisms of its motion, and the improvement of a bunch of later generations of anticancer and antiviral brokers in accordance with the guardian fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines have been, and are, contributions of significant significance to scientific science.

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Chern. 259:11022-11026. Rokita, S. , Srere, P. , and Walsh, C. , 1982. 3-Fluoro-3-deoxycitrate: A probe for mechanistic study of citrate-utilizing enzymes, Biochemistry 21:3765-3774. , Strydom, D. , and Vallee, B. , 1988. 5, Biochem. Biophys. Res. Commun. 156:530--536. Skilleter, D. , Dummel, R. , 1972. Specific enzyme inhibitors. XlV. Effects of enzymically synthesized ( - )-erythro-fluoromalic acid on malate dehydrogenase and on anion carriers of liver mitochondria, Mol. Pharmacol. 8:139-148.

Enzymatic synthesis of monofluorocitrate from p-fluoro-oxaloacetate, J. BioI. Chem. 237:3588-3596. , and Naqvi, S. , 1982. Fluorine in biomedicinal chemistry. An overview of recent advances and selected topics, in Biomedicinal Aspects of Fluorine Chemistry (R. Filler and Y. , Tokyo; Elsevier Biomedical Press, Amsterdam, pp. 1-32. Flournoy, D. , and Frey, P. , 1986. Pyruvate dehydrogenase and 3-fluoropyruvate: Chemical competence of 2-acetylthiamin pyrophosphate as an acetyl group donor to diyhydrolipoamide, Biochemistry 25 :6036-6043.

The malate synthase-catalyzed condensation of fluoroacetyl-CoA (Vmax = ~ 5 %) with glyoxylate produces an approximately equal mixture of two diastereomeric fluoromalates. This indicates that, unlike citrate synthase, malate synthase does not discriminate between the pro-R and pro-S protons of fluoroacetyl-CoA in the deprotonation step. Attack on the si face of glyoxylate results in the R-configuration for the hydroxyl group (Fig. , 1981). A similar achiral synthesis offluoromalate was reported by Keck et al.

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