Laboratory Medicine

Amyotrophic Lateral Sclerosis and the Frontotemporal by Michael J. Strong

By Michael J. Strong

During the last ten years, there was an expanding acceptance that syndromes of frontotemporal disorder (FTD) are a standard prevalence in sufferers with amyotrophic lateral sclerosis (ALS). Such syndromes could be found in as many as 60% of sufferers with ALS. Conversely, the prevalence of motor neuron disorder in sufferers with clinically natural frontotemporal dementia is more and more famous. this implies that to some degree there are overlapping syndromes within which either ALS and FTD take place in the comparable person.

This quantity summarizes the advances in our realizing of those problems, in addition to the aptitude courting among the 2. Key issues contain advances in our skill to clinically describe the frontotemporal syndromes, preclinical detection, neuroimaging, and genetics. The exploding box of latest markers in neuropathology is tested, as is the position of latest genetic mutations in DNA/RNA shipping structures. This ebook is the fundamental reference textual content for this subject, and may be of curiosity to neurologists and neurological trainees with a scientific or learn curiosity within the FTDs or ALS, neuropsychologists, neuropathologists, and researchers.

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Rao SD, Banack SA, Cox PA, Weiss JH. (2006). BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol, 201, 244–252. 87. Ly PTT, Singh S, Shaw CA. (2007). Novel environmental toxins: steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases. J Neurosci Res, 85, 231–237. 88. Karamyan VT, Speth RC. (2008). Animal models of BMAA neurotoxity: a critical review. Life Sci, 82, 233–246. 23 24 LESSONS FROM THE STUDY OF NATURAL EXPERIMENTS OF HYPERENDEMIC FOCI 89.

2. Beleza-Meireles A, Al-Chalabi A. (2009). Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives. Amyotroph Lateral Scler, 10, 1–14. 3. Tillema S, Wijnberg CJ. (1953). ‘Epidemic’ amyotrophic lateral sclerosis on Guam: epidemiologic data. Doc Med Geog Trop, 5, 366–370. 4. Horner RD, Grambow SC, Coffman CJ, et al. (2008). Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak. Neuroepidemiology, 31, 28–32. 5. Uccelli R, Binazzi A, Altavista P, et al.

Garruto RM, Swyt C, Fiori CE, Yanagihara R, Gajdusek DC. (1985). Intraneuronal deposition of calcium and aluminum in amyotrophic lateral sclerosis of Guam. Lancet, ii, 1353. 52. Garruto RM, Swyt C, Yanagihara R, Fiori CE, Gajdusek DC. (1986). Intraneuronal co-localization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism with dementia of Guam. N Engl J Med, 315, 711–712. 53. Linton RW, Bryan SR, Griffis DP, Shelburne JD, Fiori CE, Garruto RM. (1987). Digital imaging studies of aluminum and calcium in neurofibrillary tangle-bearing neurons using secondary ion mass spectrometry.

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